Family[]
Scrooge McDuck[]
Scrooge McDuck is Donald's uncle through his younger sister, Hortense McDuck. He used to live with Scrooge inside McDuck Manor at least by his pre-teens, where they spent a lot of time together when he was younger, going on many adventures with Scrooge and his sister Della. After Della's disappearance into space on a rocket Scrooge built, Donald and Scrooge had a falling out due to Donald blaming Scrooge for the disappearance of Della, even though Scrooge spent half of his fortune attempting to bring her back.
This lasted for ten years until the beginning of the series, when Donald asked Scrooge to babysit his nephews, due to almost being late for a job interview. Donald was skeptical and nervous to leave his nephews with Scrooge at first and later had his fears confirmed when he learned of Scrooge including the boys on his expedition to Atlantis. However, he eventually realized that Scrooge could also teach the boys how to survive tough situations while admitting he was overprotective. Due to an explosion on Donald's boat caused by Dewey for keeping the engine running, Scrooge agreed to let them move into McDuck Manor.
At times, Donald and Scrooge have shown to still care for one another deep down, as seen in The Most Dangerous Game...Night! when Donald and Scrooge share a brief hug over winning but try to shrug it off as nothing with a handshake soon after. Scrooge then admits he considers Donald a moocher that lives in his pool and eats his food, even though he's assisted him on a few profitable adventures. He and Scrooge mostly have a love-hate relationship, for example in The Town Where Everyone Was Nice! when he consistently hesitated to give Donald money to impress his friends but also refused to lose Donald after learning he wanted to bring the band back together. Also in The 87 Cent Solution! when the fake funeral was being held for Scrooge, Donald was the only one who wasn't told about the setup, leading him to believe he was dead. He can be seen mourning in front of the casket, running out in tears and even fainting at the sight of Scrooge still being alive, showing how much he truly still cares about his uncle's well-being.
Della Duck[]
Della is Donald's twin sister who isn't currently around, he does her the favour of being her children's guardian. Not much is said about Donald and Della's relationship, but based on Donald's behavior in The Spear of Selene!, it's shown that Donald is very sensitive about her disappearance. Last Christmas! Donald was going through a punk rock phase, and try to become mature and independent in the process, but, he ends up leaving Della behind upsetting her. Yet he sees that later and is genuinely sorry about it that he apologize for and promises to stick together from then on.
Before the events of Woo-oo!, Donald and Della were very close, as they travelled the world and went on adventures with their uncle Scrooge. Their relationship, however, had ended on a sour note for more than 10 years, as explained in The Last Crash of the Sunchaser!, when Donald was seen yelling at Della in a flashback about the risks of the outer space expedition she was intending on achieving. Della later mentions "the only person I managed to bunk with was my brother, and we fought constantly".
It is unknown whether or not they had another conversation before Della stole the Spear of Selene. At the end of The Golden Spear!, Donald is the first of the family to realize that Della is still alive when he spots the Spear of Selene landing on Earth for the first time in ages. He falls steps short of reuniting with her when his bad luck activates the Spear of Selene and he flies away in her place.
During Moonvasion!, the twins reunite after Della, Huey, Dewey, Louie and Webby accidentally find Donald stranded on a deserted island. When Donald and Della approach each other they immediately become furious with one another, Donald with Della for not getting his message and Della with Donald for his long absence. But after angrily admitting and realizing how much they've missed each the twins reconcile with a tearful hug which they haven't had in years and was overdue a long time ago.
Huey, Dewey, and Louie Duck[]
Huey, Dewey, and Louie are Donald's nephews and as well as being their uncle, Donald is also their guardian. Even though they can troublesome Donald loves them unconditionally as if they were his kids, and ten years with them has brought him to the point where Donald has become an overprotective father-figure to the triplets. In the events of Woo-oo! his protectiveness had gone to a ridiculous extent, and as seen in photographs Donald helps Dewey take his first steps while being surrounded by pillows, and when Donald is shown to have Huey wear football fatigues just to be the water boy. Yet even if he goes overboard his parental nature is in the right place. As shown time and time again that he will risk his own life to rescue his nephews.
Gladstone Gander[]
Donald and Gladstone are cousins, and as they grew up they spent a lot of time together. However, even though he's family, Donald always had a strong dislike and even envy of Gladstone's luck. During their time growing up together, whenever something good happened to Gladstone, something bad happened to Donald; this irritated Donald making him feel insignificant. Yet despite their stark difference in fortune, he would still help him out because Donald is always there for the family. This is shown in The House of the Lucky Gander!.
Fethry Duck[]
Fethry is Donald's paternal cousin who believes himself to be Donald's favorite cousin, but it is never confirmed by Donald himself. As explained in The Depths of Cousin Fethry!, Donald's adventures with Fethry often end up being pointlessly dangerous and a big waste of time, with Donald emphasizing on all the explosions that occurred during then. Nevertheless, Fethry has also assisted Donald in some of his problems including rescuing him from a deserted island with the help of his sea friend Mitzy, as well as transporting him and their family back to Duckburg to assist in the battle against the Moonlanders.
Webby Vanderquack[]
Very few interactions are shown between Donald and Webby, but Webby is known to be a fan of Donald and similar to Scrooge, idolizes him as one of the greatest adventurers of all time. As seen in The House of the Lucky Gander!, when he won, she hugged him. Then, in The Shadow War! when Donald said "Get away from my kids" as he was fighting off Magica's shadow army, there may be an implication that Donald has accepted her as his honorary niece (although he has not given her to call him Uncle Donald yet, as Scrooge did). Like his nephews, he also wants to protect Webby, for example in The Town Where Everyone Was Nice! when she was tied up by a plant tentacle he rescued Webby along with his nephews. And in The Golden Spear!, in the near end she gave him a goodbye hug when they send him to the vacation. In Quack Pack!, he said her name for the first time (but with normal voice). In Escape from the ImpossiBin!, when he saw Webby in trouble, he went as far as putting his foot down to Beakley.
Friends[]
Gyro Gearloose[]
Although Gyro is more of a friend of Scrooge, he also has a good friendship with Donald Duck in helping him with inventions and as tests in the laboratory, he also put a gadget to change his voice so that he can understand him while he speaks normally.
Storkules[]
Despite not looking Donald Duck is close friends to Storkules.
Mrs. Beakley[]
Donald Duck knew Mrs. Beakley when he was younger during his "better" time with his Uncle Scrooge. At the end of Woo-oo! when Beakley talked to her granddaughter Webby and allowed her to continue to go on adventures with Scrooge, her influence lead to Donald giving his nephews more freedom and permission to continue to go on adventures with Scrooge. However, in Daytrip of Doom! Donald and Beakley got into a fight over house rules, with Beakley getting into an argument with Donald about breaking fire laws and using up the water bill. This, in turn, caused Donald to order multiple generators for his boat, with Beakley remarking "He is going to kill himself." They finally worked together when Donald showed her the ransom note left by the Beagle Boys. When they go up against the Beagle Boys, Beakley was impressed with how tough Donald was and by the end of the episode, Donald and Beakley were talking and appeared to be getting along better than before.
Panchito Pistoles & José Carioca[]
During "The Town Where Everyone Was Nice!" Panchito and Jose are revealed to be Donald's best friends from college, with whom he made a band named The Three Caballeros. They reunite once more while Donald and his family are on a trip to Brazil to watch a legendary flower bloom. All three of them claim to be super rich and widely known for their careers, but they eventually admit to one another their low employments and status in the world. Nevertheless, the three are shown to be great friends as they work well together when defeating the blooming flower that came to life and attacked everyone while singing their signature song in the process. Even when returning home, they believe it would be a good idea to bring the band back together, but Donald's uncle Scrooge smashes Panchito's guitar (while claiming it to be because of turbulence) to ensure it wouldn't happen.
Goofy[]
In a 90s-sitcom-like alternate reality created by Gene the Genie in response to a wish made by Donald, Goofy was the McDuck/Duck family's zany next-door neighbor.
Daisy Duck[]
Donald and Daisy originally met each other during a heist set up by Louie gone wrong at Emma Glamour's It-list party. Due to a communication error, Donald and his fellow heist crew accidentally locked both him and Daisy inside an elevator together. While waiting for help, Donald and Daisy share some of their similarities about each other such has no one ever listening to what they have to say, which to Donald's surprise is when Daisy claims she can perfectly understand his voice. Donald is well known for his poor singing, but Unlike everyone else, Daisy hears Donald's voice through a different perspective, as she believes him to have a beautiful voice which she admits she can listen to all night. They fight well together, and they're both proven to have a similar ill-tempered attitude towards anything that doesn't work out their way. After the events of the heist, Donald started to get into a relationship with Daisy.
Associates[]
Jones[]
Jones used to be Donald's anger management counselor. A short time after Donald's nephews hatched, Donald wanted to try and be a good and responsible parent for them, so he decided to go to Jones to find a way to relieve his anger and sudden outbursts. Although Donald spent most of his time punching bean bags, Jones was able to teach him to form the anger he had inside him into a protective instinct. This allowed Donald to take his anger out at the most convenient times to protect his family, as the thought of someone or something intending to put harm on his family would send him into an infuriating rage. Nevertheless, Jones and Donald's relationship remains negative due to Donald's inability to pay the bills for Jones' time with him.Scrooge McDuck later turned it into positive one because he paid the bills on his behalf
Penumbra[]
Penumbra and Donald first became acquainted with one another when Donald turned up as Lunaris' prisoner, after he had accidentally landed the Spear of Selene back on the moon in "Nothing Can Stop Della Duck!" Afterwards in "What Ever Happened to Donald Duck?!," Penumbra and Donald form a temporary alliance to seek out a weakness that can disable the rockets being built for an invasion on Earth. Eventually they both manage to get to Lunaris' private hangar to look for blueprints for the rockets, but in the process discover that Lunaris had already been preparing for an invasion since before he announced it to the other Moonlanders. Unfortunately Penumbra was taken down by Lunaris soon after, leading Donald to forcefully escape from the Moon inside one of Lunaris' experimental rockets. They both reunite months later during "Moonvasion!" when Donald and his family were about to be killed by Lunaris' ship, but luckily Penumbra managed to disable it just in time using the Spear of Selene. Afterwards, they both return to McDuck Manor on Earth, where it's presumed their relationship is mutual after the Moonlanders and Duckburgians are seen making peace following the invasion.
Enemies[]
Flintheart Glomgold[]
Glomgold first starts as Donald's employer while the nephews are under the care of Scrooge. Having been used to get to Atlantis, Glomgold tries to leave him to die when the old city begins to flood.
Lunaris[]
Lunaris and Donald start off as immediate enemies after Lunaris arrests Donald when he unexpectedly arrives on the Moon. With Donald imprisoned, Lunaris shows a crueler side to Donald by shutting his beak with a muzzle-like goldpiece and threatening to place him in the gold mines for being unruly. Later, when Lunaris announces his intentions to kill the nephews to weaken Scrooge's resolve, it only fuels Donald's rage to fight him. Donald then escapes on one of Lunaris' test rockets back to Earth, while Lunaris has no intention of stopping him because of his assumption that no one could survive the ride. Nevertheless, Donald and Lunaris encounter each other one last time to put an end to one another's plans. Lunaris almost gets the angle on Donald and his family during their spaceship battle, but Penumbra saves him and disables Lunaris' ship, putting an end to Lunaris' threats on Donald and his family.