Family[]
Huey Duck[]
Huey is Louie’s oldest triplet brother (by 48 minutes and 3 seconds), and they are very different. In fact they seem to be the opposite. where Huey is hard-working, honest, and rigid, while Louie is lazy, sly, and goes with the flow. Yet, they are very close as brothers and always stick together. Despite their differences, they both hang out with each other the most, as they love to plan out everything, whether it's a checklist (in Huey's case) or a scheme (in Louie's case).
Dewey Duck[]
Dewey is Louie's immediate older triplet brother (by 48 minutes). They're very playful, mischievous and enjoy hanging out and going on adventures together. When speaking about one of his brothers, specifically when complaining or insulting one of them, he normally chooses Dewey. Often times Louie wouldn't rely on him for helping with his schemes. But Dewey's assistance in "Louie's Eleven!" by defeating Falcon Graves and his crew with a yo-yo distraction leads him to believe he truly can give him a hand with his future ideas. He has manipulated Dewey to do his chores for him, as seen in The Other Bin of Scrooge McDuck!, where he tricked Dewey into doing his laundry.
Della Duck[]
Della is Louie's mother, after finding out about her disappearance Louie along with his brothers were deeply heartbroken. After "The Shadow War!", they all moved back into the mansion and holding Della in their hearts. Although in "The Most Dangerous Game...Night!", Della's tragedy has taken a toll on Louie by becoming scared of adventuring and unsure of his as an adventurer. In "Nothing Can Stop Della Duck!", Louie eventually meets Della for the first time. At first, he thinks Della is an illusion created by Magica. Louie seemed reluctant to accept her as a mother until she saved him from the Gilded Man's rampage.
Their bond hit a snag in "Timephoon!" where Louie's time-travelling scheme to acquire historically lost treasures nearly doomed everyone and Della finally put her foot down and scolded Louie for his greed and selfishness while Louie threw a barb at his mother for how her own recklessness got her lost for so many years. Della then grounds Louie and declares his "company", Louie incorporated, done before sending the grumbling Louie to his room. However, he was ungrounded at the end of "GlomTales!" when Della found out that some of his schemes can be helpful after seeing him swindle the villains out of their fortunes.
Louie even helps Della remain calm in Moonvasion! with her own song and they work together properly in Escape from the ImpossiBin! when testing out Scrooge's new secruity system to ward of F.O.W.L..
Donald Duck[]
Donald is Louie's uncle and guardian/father figure for most of his life, and even though Louie doesn't think of him as cool, he still loves him regardless. This is well shown in the episode "The House of the Lucky Gander!" where he claims that Gladstone Gander, is their best (non-rich) Uncle, excluding Donald in front of him, creating a jealous Donald. However, Louie realized Donald is the better uncle because of his heart and perseverance, he then cheers him on through the rest of the race.
Scrooge McDuck[]
Scrooge McDuck is Louie's great-uncle, Louie cherishes his great uncle and holds him up in high regard especially since he's rich, and loves him back yet Scrooge has shown to be a bit short with him. In the episode "The Great Dime Chase!" Scrooge is shown to be annoyed by Louie's lazy and spoiled attitude, that it made Scrooge want to teach him that hard honest work is the most rewarding. Louie seems to regard Scrooge's wealth and possessions as his own by association and has no qualms about exploiting it.
Gladstone Gander[]
Louie initially idolizes Gladstone because of his natural good luck, which allows him to continuously receive good fortunes and attain money without ever putting any real work into it. during "The House of the Lucky Gander!" Louie is further impressed at Gladstone's charms when he strikes it big at the casino, but Gladstone also reveals to show little care for bonding with Louie after it's revealed his main intentions were on Donald and his bad luck. This leads Gladstone to unknowingly leave a bad impression on himself in the eyes of Louie, as Louie not only encourages Donald to beat him in a racing challenge to save him and the rest of the family over Gladstone, but he also considers luck to be an overrated concept by the end of their adventure.
Webby Vanderquack[]
In "Woo-oo!", Webby attacks him and his brothers, Louie thought of Webby to be weird but also interesting and they turn into good friends. Though in "Daytrip of Doom!", Louie sees Webby as a handful and even states this in front of her, yet he later accepts her quirkiness and they become better friends. Although in "The Living Mummies of Toth-Ra!", Louie and Webby were stuck together and had to escape the many dangers of the tomb of Toth-Ra. Webby gets irritated by Louie for always seeking to manipulate situations to his own benefit, but they later resolve their issues and help each other out.
Friends[]
Lena Sabrewing[]
Even though Louie knows little about Lena, he does like her regardless. Although, when they first met, Lena jumped him and scared him. Later, when she tricked the entire Beagle family, he admires her slick wits and Louie even called her his "new favourite".
Goldie O'Glit[]
In "Happy Birthday, Doofus Drake!", Louie turned to Goldie to learn more of conning and swindling from her after she finds out he was invited to the birthday party of Doofus Drake (where the goodie bags are literally bags of treasure, artifacts, and money). They impress each other and even bond a little though Goldie still winds up conning Louie even after he helped her out. Though, unbeknownst to Louie, Goldie put Louie's picture into her wallet, right next to a picture of Scrooge, indicating she does have a sincere fondness for him.
Doofus Drake[]
When meeting on "Day of the Only Child!" Louie and Doofus are very much the same. They both are rich, they both love doing what they want, and both are lazy. But when Louie finds out that Doofus is mad with power and money, he wants to leave. He is warned by Doofus's parents to not go against him. Eventually, Louie and his brothers escape, never wanting to be with him again. It has also been said in "Treasure of the Found Lamp!", that Doofus had originally used the lamp as a syrup boat for his "One Man Flapjack Jamboree", but then threw it away after it became empty and had his Father, or his butler, use his hands as his syrup boat to pour the syrup onto his flapjacks. it is until “Life and Times of Scrooge McDuck” that they reconcile and stop being enemies
B.O.Y.D.[]
Louie first met B.O.Y.D. in "Happy Birthday, Doofus Drake!" When he was "created" by Mark Beaks in order to attend Doofus's birthday party to get the gift bags. When he and Goldie find out that B.O.Y.D. is a robot, Louie exposed him in front of Doofus, causing him to short circuit into the pool and Beaks to get eliminated. After this, Doofus forced B.O.Y.D. to kill Louie by using him as a pinata until Goldie saved him. In the end, when she was kidnapped by Doofus as his new Geememama, B.O.Y.D. helped Louie save her and he gave him to Doofus as a baby brother for his birthday, much to his dismay.